Circumsporozoite protein gene diversity among temperate and tropical Plasmodium vivax isolates from Iran
نویسندگان
چکیده
منابع مشابه
diversity of merozoite surface protein-3β gene of plasmodium vivax isolates from iran
background: plasmodium vivax malaria accounts for approximately 88% of malaria cases in iran. there is limited information on genetic diversity of p. vivax in the country and a need to develop and apply an effective vaccine against the disease is necessary. among many potential candidates, msp -3β gene is promising target. this study was designed and carried out to determine the variation of...
متن کاملgenetic diversity in the circumsporozoite protein gene of plasmodium falciparum from major endemic regions of iran
circumsporozoite protein (csp) is one of the stage specific antigens, which is used for the development of vaccines and to investigate the genetic diversity in plasmodium falciparum malaria parasite. polymerase chain reaction was used for typing of csp genes on 67 positive falciparum malaria patients from sistan and baluchistan province of iran. three fragments were detected for csp gene. twent...
متن کاملVariants of the Plasmodium vivax circumsporozoite protein (VK210 and VK247) in Colombian isolates.
Phenotypic diversity has been described in the central repeated region of the circumsporozoite protein (CSP) from Plasmodium vivax. Two sequences VK210 (common) and VK247 (variant) have been found widely distributed in P. vivax isolates from several malaria endemic areas around the world. A third protein variant called P. vivax-like showing a sequence similar to the simian parasite P. simiooval...
متن کاملPlasmodium vivax dhfr Mutations among Isolates from Malarious Areas of Iran
The use of sulfadoxine and pyrimethamine (SP) for treatment of vivax malaria is uncommon in most malarious areas, but Plasmodium vivax isolates are exposed to SP because of mixed infections with other Plasmodium species. As P. vivax is the most prevalent species of human malaria parasites in Iran, monitoring of resistance of the parasite against the drug is necessary. In the present study, 50 b...
متن کاملMOLECULAR SURVEILLANCE OF Plasmodium vivax AND Plasmodium falciparum DHFR MUTATIONS IN ISOLATES FROM SOUTHERN IRAN
In Iran, both Plasmodium vivax and P. falciparum malaria have been detected, but P. vivax is the predominant species. Point mutations in dihydrofolate reductase (dhfr) gene in both Plasmodia are the major mechanisms of pyrimethamine resistance. From April 2007 to June 2009, a total of 134 blood samples in two endemic areas of southern Iran were collected from patients infected with P. vivax and...
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ژورنال
عنوان ژورنال: Tropical Medicine and International Health
سال: 2006
ISSN: 1360-2276,1365-3156
DOI: 10.1111/j.1365-3156.2006.01613.x